The CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirms BPAs safety. Scientific research shows that in humans, BPA is quicklymetabolized and eliminated from the body it does not accumulate in blood or tissues. Bisphenol-A, commonly abbreviated as BPA, is an organic compound with the chemical formula (CH 3) 2 C (C 6 H 4 OH) 2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price, Find Details and Price about Bisphenol-a-Co-Epichlorohydrin 106-89-8 from Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price - Shanghai Guanru Chemical Co., Ltd. Table 1, Table 2 present the . They are produced by the addition of - unsaturated carboxylic acids to epoxy resins. bisphenol A type Epoxy resin depending on the molecular weight and degree of polymerization n, the resin is yellow to amber transparent viscous liquid (or solid), the average molecular weight in the production of 300~700, n; 2, softening point below 50 is called low molecular weight epoxy resin (I. E. Soft resin); Molecular weight above 1000, n>2, those having a softening point above 60 C. Brand Names: Not applicable . Update on Bisphenol A (BPA) for Use in Food Contact Applications, January 2010; March 30, 2012; Updated March 2013; July 2014; November 2014. Epub 2014 Feb 4. c) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. As can be seen from above, the product is bisphenol A diglycidyl ether when there is sufficient epichlorohydrin and enough sodium hydroxide as the catalyst. Many of these studies addressed how the body disposes of or metabolizes BPA. [12] A common criticism is that industry-sponsored trials tend to show BPA as being safer than studies performed by academic or government laboratories,[14][75] although this has also been explained in terms of industry studies being better designed. Furthermore, composite . Strong, shatter-resistant polycarbonate is used for helmets and protective sports visors to help protectchildren and athletes from injuries. Liquid Epoxy Resins Show entries Before sharing sensitive information, make sure you're on a federal government site. . [27], In terms of the endocrine disruption controversy, the British biochemist Edward Charles Dodds tested BPA as an artificial estrogen in the early 1930s. About 6570% of all bisphenol A is used to make polycarbonate plastics,[9][10] which can consists of nearly 90% BPA by mass. The performance represented by each part of the Bisphenol A-type epoxy resin is shown here: Araldite? Health concerns have also been raised about these substitutes. . Per the diagram below, most epoxy resins are made by reacting Bisphenol A (BPA) with an excess of epichlorohydrin so the end groups are glycidyl ethers. Chemical compound used in plastics manufacturing, InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, Except where otherwise noted, data are given for materials in their, "Chemical Fact Sheet Cas #80057 CASRN 80-05-7", Ullmann's Encyclopedia of Industrial Chemistry, "Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A", "Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A", "The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands", "Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing", "Pit and fissure sealants for preventing dental decay in permanent teeth", "Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review", " i ", "Condensationsproducte aus Ketonen und Phenolen", "The politics of plastics: the making and unmaking of bisphenol a "safety", "Synthetic strogenic Agents without the Phenanthrene Nucleus", "Molecular Structure in Relation to Oestrogenic Activity. The hydroxy group may be derived from aliphatic diols, polyols (polyether polyols), phenolic compounds or dicarboxylic acids. It is commonly used in curing fast-drying epoxy resin adhesives. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. Due to its especially thick natural consistency, there will commonly be additives and diluents which are added into the Bisphenol-A epoxy formula to enhance workability and adhesion. Concerns about the health effects of BPA have led some manufacturers replacing it with other bisphenols, such as bisphenol S and bisphenol F. These are produced in a similar manner to BPA, by replacing acetone with other ketones, which undergo analogous condensation reactions. Developmental treatment with bisphenol A or ethinyl estradiol causes few alterations on early preweaning measures. Uses of all substances that migrate from packaging into food, including BPA, are subject to premarket approval by FDA as indirect food additives or food contact substances. It belongs to the phenol class of aromatic organic compounds. FDAs current perspective, based on its most recent safety assessment, is that BPA is safe at the current levels occurring in foods. Bisphenol A-type epoxy resin is bisphenol A and epichlorohydrin under the action of sodium hydroxide condensation derived. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. [25], In 1934, workers at I.G. 250/ Ton Get Latest Price. . According to the ratio of raw materials, the reaction conditions and adopt the same method can be obtained with different degrees of polymerization of low molecular weight viscous liquid and high . Federal government websites often end in .gov or .mil. The .gov means its official. 2010 Oct 1;248(1):1-11. h) Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. Make any industrial chemical reactions run smoothly with the organic intermediate compounds available at Alibaba.com's chemical store. When government scientists review studies to make a safety conclusion, they look at the weight of the evidence, meaning the information available from all sources, and how well each study was conducted. MAIN APPLICATIONS Bisphenol A Epoxy is widely used in the manufacture of: Epoxy resins; Phenolic resins . Uses of all substances that migrate from packaging into food,. [95] BPA in sediment degrades most slowly of all, particularly where this is anaerobic. Properties of copolymer epoxy resins. BPA is an industrial chemical used to make polycarbonate, a hard, clear plastic, which is used in many consumer products. [1] This draft assessment was reviewed by a Subcommittee of FDAs Science Board, which released its report at the end of October 2008. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. [36] It may be purified by recrystallisation from acetic acid with water. Polyols can be compounds such as 1,4-butanediol. Every day, people are exposed to a variety of activities or products that could, under certain circumstances, cause harm. [22] BPA-free plastics have also been introduced, which are manufactured using alternative bisphenols such as bisphenol S and bisphenol F, but there is also controversy around whether these are actually safer. [74] It binds to both of the nuclear estrogen receptors (ERs), ER and ER. The ACC mark, Responsible Care, the hands logo mark, CHEMTREC, TRANSCAER, and americanchemistry.com are registered service marks of the American Chemistry Council, Inc. May also be known as: Polycarbonate, Epoxy Resins. Thanks to their high strength, versatility, and excellent adhesion to a variety of surfaces, epoxy resins have gained wide acceptance in diverse applications (coatings, electrical, casting resins, composites, etc.). The method is a modification of NIOSH P&CAM If youve ever read a news article or blog post about chemicals, you may have heard the oft-cited claim that there are 84,000 chemicals in commerce but only 200 of these have been tested for safety. It is alcohol, ketone and ether soluble but presents low solubility in water and carbon tetrachloride. Whether you're producing perfume or PVC plastics, the chances are intermediates will . These may be incorporated at low levels in vinyl ester resins to change their physical properties[45] and see common use in dental composites and sealants.[46][47]. If you are giving a presentation about an environmental health topic or Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity, similar to glass. The lowest molecular weight an epoxy resin of the DGEBA type can have is 340, but if two elements together can form different molecular weights when they react, the epoxy resin will contain a mixture of epoxy molecules of varying lengths. BPA has also been found to act as an agonist of the GPER (GPR30). Because of its extreme durability and strength, polycarbonate plastic is particularly useful for making component parts that need to be thin and light, but strong. Among the non-food sources, exposures routes include through dust,[10] thermal paper,[20] clothing,[19] dental materials,[69] and medical devices. Polymerisation is achieved by a reaction with phosgene, conducted under biphasic conditions; the hydrochloric acid is scavenged with aqueous base. It is also a component in metal can coatings, which protect the food from directly contacting metal surfaces. It is classified as a bisphenol, and a close molecular analog of Bisphenol A (BPA). fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. It can also be used in the formation of solid polymeric electrolyte for potential application in electrochemical devices. Bisphenol-F can further link generating tri- and tetra-and higher phenol oligomers. Empirical Formula (Hill Notation): C21H24O4 CAS Number: 1675-54-3 Molecular Weight: 340.41 Beilstein: 299026 EC Number: 216-823-5 MDL number: MFCD00080480 PubChem Substance ID: 57654090 NACRES: NA.77 Pricing and availability is not currently available. Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. [65][24], As a result of the presence of BPA in plastics and other commonplace materials, most people are frequently exposed to trace levels of BPA. It belongs to the phenol class of aromatic organic compounds. 2011 Nov 15;257(1):122-36. i) Doerge DR, Vanlandingham M, Twaddle NC, Delclos KB. It is also known to exhibit strong endocrine-disrupting ability. Heightened interest in the safe use of BPA in food packaging has resulted in increased public awareness as well as scientific interest. NIEHS sponsors and co-sponsors scientific meetings, conferences, and events throughout the year. FDAs regulatory Centers and FDAs National Center for Toxicological Research continue to pursue a set of studies on the fate of BPA in the body from various routes of exposure and the safety of low doses of BPA, including assessing novel endpoints where questions have been raised. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. Poly(Bisphenol-A-co-epichlorohydrin) (PBE) is an epoxy based resin that is a phenoxy polymer derived from bisphenol A and epichlorohydrin. There is no scientific basis to say that BPA-free products are safer than products with BPA. NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. NIEHS offers a broad range of job opportunities, career enhancement programs, and research training grants and programs in environmental health sciences and administration. Order: 200 kg Qingdao Cemo Technology Develop Co., Ltd. NIEHS provides many opportunities for funding to individual researchers, organizations, and businesses. Paper recycling can be a major source of release when this includes thermal paper,[9][97] leaching from PVC items may also be a significant source,[93] as can landfill leachate. [23][24], Bisphenol A was first reported in 1891 by the Russian chemist Aleksandr Dianin. PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. When dropping is completed within half an hour, heat it for 12-24 hours under temperature 70-80C Stop the heating after bisphenol A is completely disappeared validated by TLC method. [26] The utilization of BPA further expanded with discoveries at Bayer and General Electric on polycarbonate plastics. Bisphenol A is the chemical product of combining one acetone unit with two phenol groups. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. MATERIAL SAFETY DATA SHEET West System Inc. MSDS #105-13a Last Revised: 26APR13 1. . Neurotoxicol Teratol. Order: 18 Tons Shandong Near Chemical Co., Ltd. View larger video & image Contact Now Hot Sale Bisphenol a CAS No. High-performance epoxy resins are used to make aircraft, cars, bicycles, boats, golf clubs, skis and snowboards durable, flexible and strong. [42] This process converts the individual molecules of BPA into large polymer chains, effectively trapping them. While there have been many hundreds of studies on BPA, none has shown a direct cause-and-effect relationship between BPA and any human health effects. 2012 Jun 1;211(2):114-9. g) Doerge DR, Twaddle NC, Woodling KA, Fisher JW. J Appl Polym Sci . bisphenol a epoxy resin price are designed to form other substances and play a crucial role in numerous important reactions. Farbenindustrie reported the coupling of BPA and epichlorohydrin. In recent years, many claims have been made about the health effects of BPA. People are generally exposed to minute levels of BPA, mostly from the ingestion of food or beverages that have been in contact with materials manufactured with BPA. Add bisphenol A and epichlorohydrin in the amount of 1:4 into a three-necked flask equipped with a reflux device, place it in a constant-temperature oil bath, melt it with 70 C of heat, and dropwise 28.57% aqueous sodium hydroxide solution with a dropping funnel, in which the ratio of the amount of sodium hydroxide and bisphenol A is 4:1. The condensation of acetone (hence the suffix 'A' in the name)[32] with two equivalents of phenol is catalyzed by a strong acid, such as concentrated hydrochloric acid, sulfuric acid, or a solid acid resin such as the sulfonic acid form of polystyrene sulfonate. [7], BPA has been found to interact with a diverse range of hormone receptors, in both humans and animals. [74] These interactions are all very weak, but exposure to BPA is effectively lifelong, leading to concern over possible cumulative effects. The CLARITY Study, the largest study ever done on BPA and conducted by FDA experts, confirms that BPA is safe, and supports the agencys one word answer to the question: Is BPA safe?: Yes. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. Di- and polyols lead to . 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[3]NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A, NIH Publication No. 2011 Sep 15;255(3):261-70. e) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. The consensus of major government agencies around the world is that BPA is safe as used in food-contact applications. Chemical Identity. 2005 2022 American Chemistry Council, Inc. Epoxy resins made with BPA are tough and readily adhere to metal surfaces, making them excellent materials for protective coatings. Dianin in 1891. Published September 2022. Some of this is further reacted with methacrylic acid to form bis-GMA, which is used to make vinyl ester resins. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. Rapid Commun Mass Spectrom. Many BPA-containing materials are non-obvious but commonly encountered,[17] and include coatings for the inside of food cans,[18] clothing designs,[19] shop receipts,[20] and dental fillings. View our page to search various areas of interest and methodology. Background. Bisphenol A diglycidyl ether (DGEBA) can be called a small-molecule adhesive. Parents and caregivers can make the personal choice to reduce exposures of their infants and children to BPA: This content is available to use on your website. FDA continues to review the available information and studies on BPA. PA is also used in the production of epoxy resins. Chemical Economics Handbook. Pathways include photo-oxidation, or reactions with minerals such as goethite which may be present in soils and sediments. In fact, the Federal Trade Commission has specifically cautioned that free-of claims may deceive consumers by falsely suggesting that the marketer has improved the product by removing the substance.. Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Bisphenol A (BPA): Use in Food Contact Application, Summary of FDAs Current Perspective on BPA in Food Contact Applications, Overview of BPA Usage in Food Contact Applications, Increasing Our Understanding about the Biology and Metabolism of BPA, Food Additive Regulations Amended to No Longer Provide for the Use of BPA-Based Materials in Baby Bottles, Sippy Cups, and Infant Formula Packaging, based on its most recent safety assessment, Final report for the review of literature and data on BPA, 2014 Updated Review of Literature and Data on Bisphenol A, 2012 Updated Review of Literature and Data on Bisphenol A, Updated Review of the Low-Dose Literature (Data) on Bisphenol A and Response to Charge Questions Regarding the Risk Assessment on Bisphenol, Draft Assessment of Bisphenol A for Use in Food Contact Applications, Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. 2012 May-Jun;34(3):331-7. l) Patterson TA, Twaddle NC, Roegge CS, Callicott RJ, Fisher JW, Doerge DR. Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus monkeys. Developed physiologically based pharmacokinetic models that can be used to predict the level of internal exposure to the active and inactive forms of BPA. Structural formula Name CAS Reactants; Bisphenol AF: 1478-61-1: Phenol: Hexafluoroacetone: Bisphenol F: 620-92-8: Phenol: In the fall of 2014, FDA experts from across the agency, specializing in toxicology, analytical chemistry, endocrinology, epidemiology, and other fields, completed a four-year review of more than 300 scientific studies. The performance of specialized collections of bisphenol A epoxy resin system components in the evaluation of workers in an occupational health . How does BPA get into the body? More than 140,000 products, 270,000 supply sources and 4,400 company addresses. Formula: CAS CAS: Chemical Abstract Service Registry Number . Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. You can also browse global suppliers,vendor,prices,Price,manufacturers of Bisphenol A epoxy resin(). Therefore, they are effective adhesion for most substrates such as glass, ceramics, silicon wafers, and polymer materials. These studies also addressed questions about how long it takes for the body to dispose of BPA. Recently, FDA granted two petitions requesting that FDA amend its food additive regulations to no longer provide for the use of certain BPA-based materials in baby bottles, sippy cups, and infant formula packaging because these uses have been abandoned. Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). Bisphenol A is a chemical compound containing two phenol functional groups. The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. CAS number(s): 55818-57- . [8] Schug et al. With more than half of the global demand, the Asian market will . Jun 1 ; 211 ( 2 ):114-9. g ) Doerge DR, Vanlandingham M, Fisher.. On BPA, shatter-resistant polycarbonate is used to make vinyl ester resins circumstances, cause harm MSDS # Last... Bayer and General Electric on polycarbonate plastics world is that BPA is safe as in... Perfume or PVC plastics, the Asian market will events throughout the.... For the body disposes of or metabolizes BPA has also been raised about these substitutes carboxylic to... Epoxy resin is shown here: Araldite with two phenol functional groups adult rats! 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